Summer sun. Evening walks. And… mosquito bites. 🦟 - just seeing this emoji probably makes you itch.

That telltale itch isn’t just annoying, it’s your immune system in overdrive. What if you could quiet the inflammation using the power of plants?

At MARK Los Angeles, we turn to flavonoids, specifically EGCG (from green tea) and quercetin (found in apples, onions, and more), to help interrupt the itch response before it spirals. These two powerful flavonoids are in our E.Q. Rescue Serum. Here's how it works.

What Makes a Mosquito Bite Itch?

When a mosquito bites, it injects saliva that triggers an immune reaction. Mast cells rush to the scene and release histamine, a key chemical that causes itching, swelling, and redness. Histamine is just the beginning.

Your skin's immune system also ramps up pro-inflammatory cytokines like:

• IL-4 and IL-13 – drive allergic inflammation

• IL-31 – a major “itch” signal that sensitizes nerve endings

• TNF-α and IL-6 – create redness and prolong swelling

All of this means that even a tiny bite can feel like a big deal.

Flavonoid Power: EGCG + Quercetin

EGCG (Epigallocatechin gallate)

• A potent green tea flavonoid

• Stabilizes mast cells, reducing histamine release

• Inhibits cytokines like IL-6, TNF-α, and IL-31

• Soothes oxidative stress and reduces redness

Quercetin

• Found in apples, red onions, and capers

• Acts as a natural antihistamine

• Suppresses IL-4 and IL-13, calming the Th2-type immune response

• Reduces itch-related nerve sensitivity

Together, EGCG and quercetin in our E.Q. Rescue Serum address both the cause and the sensation of a mosquito bite: calming immune overreaction and reducing the skin’s response to histamine.

Why We Deliver Flavonoids Differently

Flavonoids are notoriously hard to absorb through the skin. That's why we use XDF™, our transdermal flavosome delivery system, to bring EGCG and quercetin deeper into the skin where inflammation starts.

No sticky menthol. No steroids. Just plant active ingredients.

Bottom Line

If you’re looking for a smarter way to soothe summer skin, flavonoids like EGCG and quercetin offer targeted, calming relief. Whether it’s a mosquito bite, a mystery rash, or just a little overexposure, the plant world has you covered and MARK Los Angeles delivers it where it counts.