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Pharma-grade skincare <br>that fights flare-ups

Pharma-grade skincare
that fights flare-ups

Powered by patent-pending XDFTM technology to reduce and protect from irritation and break-outs

DERMATOLOGIST RECOMMENDED

EWG-VERIFIED

CLINICALLY TESTED

AVAILABLE AT FORMULA FIG

Clinically proven results powered by our patent-pending XDFTM delivery system.

AI,24

  • Reduced inflammation & redness
  • Improved active acne
  • Balanced skin health

Naila, 27

  • Balanced skin microbiome
  • Improved tone & texture
  • Reduced breakouts and redness

Mia, 34

  • Reduced redness and visible inflammation
  • Faster visible recovery through the flare cycle
  • Improved comfort without dryness or cracking

Pharmaceutical discipline, not cosmetic convention

Pharmaceutical R&D platform

End-to-end product development led by scientists with drug-delivery expertise, from molecule selection to finished formulation.

Independent, third-party testing

Key claims supported by external labs and clinical partners to ensure objectivity and reproducibility.

Biological validation, not perception

Performance measured through permeability studies, cellular assays, and clinical evaluation, not consumer surveys alone.

Mechanism-first formulation

We explain not just what works, but why it works, down to delivery, absorption, and biological response.

We believe credibility should be quantifiable. Here’s what backs MARK so far.

400×

Better Vs. Traditional Skincare: Independent flux measurements vs. published literature baseline

95-100%

Inflammatory marker reversal - IL-6, IL-8, TNF-α, CRP suppression in stressed fibroblast assays

75%

Transdermal delivery: Franz Cell studies confirm 75% of applied flavonoids reach viable skin tissue

20+

Years Pharmaceutical R&D - Gilead Sciences (HIV therapeutics) + Nucleo Life Sciences (clinical-stage programs)

XDF™
Pharmaceutical delivery, optimized for skin.

XDF™ (Transdermal Flavosomes) is a patent-pending delivery system derived from pharmaceutical drug-delivery science. It dissolves, stabilizes, and transports bioactive molecules through the skin barrier so they can perform where inflammation, repair, and regeneration actually occur.

Engineered by drug developers, not beauty marketers.

After two decades in pharmaceutical drug delivery, our founder applied the same scientific rigor to skincare.


The goal wasn’t trendy ingredients or better packaging. It was to build formulas that actually reach their target and work safely, consistently, and measurably.

Respectful by design.

Every MARK formula is engineered to be effective enough to solve visible conditions, and gentle enough for daily use.

No harsh actives

No unnecessary fragrance

No aesthetic filler

What people are saying

Individual results may vary

Frequently Asked Questions

What is XDF™?

XDF™ is MARK’s proprietary delivery system developed from pharmaceutical drug-delivery science. Based on pharmaceutical drug-delivery science, it transports flavonoids into dermis without barrier disruption.

How is MARK different from traditional skincare?

Traditional skincare focuses on surface effects. MARK is engineered for absorption and validated through permeability studies, cellular assays, and clinical evaluation.

What skin concerns does MARK address?

Breakouts, redness, irritation, barrier disruption, and recurring flare-ups driven by inflammation.

Is MARK safe for sensitive skin?

Yes. All formulas are designed to be effective without being aggressive and are free from fragrance, essential oils, and unnecessary additives.

How long does it take to see results?

Some users notice calmer skin within days. Sustained improvements typically develop with consistent use over several weeks.

Why doesn’t MARK market active percentages?

Because delivery matters more than concentration. Most brands list 10-20% vitamin C to compensate for 0-5% absorption. We engineer delivery systems that work at lower, safer concentrations—75% of applied dose reaches target tissue allowing us to optimize for a lower dose.

What does "75% transdermal delivery" mean?

In Franz Cell studies (FDA gold standard for topical delivery), 75% of applied flavonoids crossed excised human skin into the receptor chamber at 24 hours. This confirms actives reach viable dermis, not just surface. Conventional formulations typically achieve 1-5%.

How is 400× better delivery possible?

Published literature shows conventional flavonoid formulations deliver 0.1-2 µg/cm²/hr. XDF™ achieves 418 µg/cm²/hr in Franz Cell studies. That's 200-4,000× higher flux. Even conservative estimates accounting for methodology differences indicate 50-200× improvement—fundamentally different transport kinetics.

Is this actually pharmaceutical-grade?

Our development process uses pharmaceutical methodologies: FDA-standard Franz Cell testing, BioMAP validation platforms, stressed fibroblast assays, and clinical trials. Our founder developed FDA-approved drugs at Gilead Sciences. The products are cosmetics, but the science is drug development rigor.